Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
Optimal dilution of the Histone antibody should be determined by the researcher.
1. Staining of formalin/paraffin tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.3. View the recombinant form of this Histone H1 antibody.
Nuclei of human leukemia biopsy cells were used as the immunogen for the Histone H1 antibody.
Store the Histone antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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NSJBio | R35720-100UG | NPFFR1Antibody | 100ug |
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NSJBio | R35736-100UG | PSPHAntibody | 100ug |
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NSJBio | R35738-100UG | Wfdc1Antibody | 100ug |
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NSJBio | R35742-100UG | FAFAntibody | 100ug |
NSJBio | R35744-100UG | Cntn4Antibody | 100ug |
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NSJBio | R35750-100UG | RIG1Antibody | 100ug |
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NSJBio | R35752-100UG | IL-21Antibody | 100ug |
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在免疫检测中:由于缺少Fc段,Fab不能沉淀抗原,也不能被活体的免疫细胞所识别;但拥有小分子量和交叉反应小的优点,因此常用于放免中的功能研究,也用于阻断细胞、组织内源性的免疫球蛋白及在多重免疫标记中,一抗来源于同一种属时,阻断已经暴露的IgG抗原决定簇;在实际临床应用中:目前临床应用的全抗大多数是所谓人源化抗体,也就是使用的是人IgG的骨架,但是可变区插入的是小鼠的和抗原结合的片段。虽然人源化抗体避免了种属之间的反应,但是同种属之间反复或者长期使用,由于Fc片段的存在还是可能产生自身抗体,所以人们就使用木瓜酶消化IgG,得到Fab片段,理论上Fab片段保证了抗体和抗原结合的特性,但是避免了自身抗体的可能,因为没有Fc段,片段较小,免疫原性较小。但是由于分子量较小,因此在体内代谢很快,也就是作用时间短。如果是长期使用,也就增加了用药的次数。
专精免疫学,有问题请追问!
作用:(1)特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤.然而,抗体可通过与病毒或毒素的特异性结合,直接发挥中和病毒的作用. (2)激活补体:IgM、IgG1、IgG2和IgG3可通过经典途径激活补体,凝聚的IgA、IgG4和IgE可通过替代途径激活补体. (3)结合细胞:不同类别的免疫球蛋白,可结合不同种的细胞,产生不同的疚,参与免疫应答. (4)可通过胎盘及粘膜:免疫球蛋白G(IgG)能通过胎盘进入胎儿血流中,使胎儿形成自然被动免疫.免疫球蛋白A(IgA)可通过消化道及呼吸道粘膜,是粘膜局部抗感染免疫的主要因素. (5)具有抗原性:抗体分子是一种蛋白质,也具有刺激机体产生免疫应答的性能.不同的免疫球蛋白分子,各具有不同的抗原性. (6)抗体对理化因子的抵抗力与一般球蛋白相同:不耐热,60~70℃即被破坏.各种酶及能使蛋白质凝固变性的物质,均能破坏抗体的作用.抗体可被中性盐类沉淀.在生产上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白,再经透析法将其纯化. (7)通过与细胞Fc受体结合发挥多种生物效应 ①调理作用 IgG、IgM的Fc段与吞噬细胞表面的FcγR、FcμR结合,增强其吞噬能力,通常将抗体促进吞噬细胞吞噬功能的作用称为抗体的调理作用 (opsonization). ②发挥抗体依赖的细胞介导的细胞毒作用
各种不同类别的免疫球蛋白分子都含有四条多肽链组成的基本结构单位,即由两条重链(heavy chain, H链)和两条轻链(light chain, L链)通过不同数目的二硫键结成Y形。在抗体分子的N端,不同抗体分子的氨基酸组成和顺序都是不同的,此区为“多变区“(variable region, V区),它是抗体分子与抗原决定簇的结合部位。由于抗体多变区这一结构特点,决定了它对抗原分子“识别功能”的多样性;不同抗体分子的C端结构基本恒定,称为“稳定区”(constant region, C区)。当抗原与抗体结合时,抗体分子发生变构效应和集聚作用,使稳定区的某些部位暴露出来,并立即发生一系列免疫生理效应,如固定补体,促进对抗原分子的吞噬、溶解和清除作用。
Virus,HIV),顾名思义它会造成人类免疫系统的缺陷。aware可自测不用抽血祝您健康天 猫!
科学家在针对这种免疫系统缺陷的研究依然一筹莫展