Adipogen/Actinomycin D/BVT0089M005/5 mg
ProductDetails | |
---|---|
Synonyms | ActinomycinIV;ActinomycinC1;Dactinomycin |
ProductType | Chemical |
Properties | |
Formula | C62H86N12O16 |
MW | 1255.4 |
MerckIndex | 14:2800 |
CAS | 50-76-0 |
RTECS | AU1575000 |
Source/HostChemicals | IsolatedfromStreptomycesparvulus. |
PurityChemicals | ≥98%(HPLC) |
Appearance | Redshinycrystals. |
Solubility | SolubleinDMSO,100%ethanolormethanol. |
Identity | Determinedby1H-NMR. |
Declaration | ManufacturedbyBioViotica. |
OtherProductData | Sensitivetostrongacidsandbases. |
InChiKey | ZOWMRHVAQGTFTG-IZRKADTCSA-N |
ShippingandHandling | |
Shipping | AMBIENT |
ShortTermStorage | +4°C |
LongTermStorage | +4°C |
HandlingAdvice | Keepcoolanddry. Protectfromlightwheninsolution. |
Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Afterreconstitutionprotectfromlightat-20°C. |
Documents | |
MSDS | DownloadPDF |
ProductSpecificationSheet | |
Datasheet | DownloadPDF |
- Antibiotic.
- Antitumorcompound[2].
- Cytotoxic[2].
- Apoptosisinducer[1,2,6,7].
- RNAsynthesisinhibitor[4].
- DNAintercalatingagent[3,5].
- Mcl-1expressioninhibitor[8]
- p53pathwayactivator[9].
ProductReferences
- ApoptosisinducedbyActinomycinD,CamptothecinorAphidicolincanoccurinallphasesofthecellcycle:J.M.Glynn,etal.;Biochem.Soc.Trans.20,84S(1992)
- ActinomycinDinducesapoptosisandinhibitsgrowthofpancreaticcancercells:J.Kleeff,etal.;Int.J.Cancer86,399(2000)
- InfluenceofDNAbasesequenceonthebindingenergeticsofactinomycinD:S.A.Bailey,etal.;Biochemistry32,5881(1993)
- EffectofactinomycinonRNAsynthesisandantibodyformationintheanamnesticresponseinvitro:J.D.Smiley,etal.;J.Exp.Med.119,881(1964)
- NMRSolutionStructureofaDNA-ActinomycinDComplexContainingaNon-Hydrogen-BondingPairintheBindingSite:S.L.Cravens,etal.;J.Am.Chem.Soc. 132,17588 (2010)
- ActinomycinDupregulatesproapoptoticproteinPumaanddownregulatesBcl-2mRNAinnormalperipheralbloodlymphocytes:I.Kalousek,etal.;AnticancerDrugs18,763(2007)
- ActinomycinDenhancesTRAIL-inducedcaspase-dependentand-independentapoptosisinSH-SY5Yneuroblastomacells:M.J.Wang,etal.;Neurosci.Res.59,40(2007)
- ActinomycinDsynergisticallyenhancestheefficacyoftheBH3mimeticABT-737bydownregulatingMcl-1expression:K.E.Olberding,etal.;CancerBiol.Ther.10,930(2010)
- Specificactivationofthep53pathwaybylowdoseactinomycinD:M.L.Choong,etal.;CellCycle8,2810(2009)
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发布于 : 2021-09-06
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