Adipogen/antiCathepsin D, pAb/YIFLFPA0204/100 µl
ProductDetails | |
---|---|
Synonyms | CTSD;CPSD;EC=3.4.23.5 |
ProductType | PolyclonalAntibody |
Properties | |
Immunogen/Antigen | RecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli. |
Application | WesternBlot(1:5,000) |
Crossreactivity | Human Rat |
PurityDetail | Affinitypurification. |
Concentration | 1mg/ml |
Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
Declaration | ManufacturedbyAbFrontier |
ShippingandHandling | |
Shipping | BLUEICE |
ShortTermStorage | +4°C |
LongTermStorage | -20°C |
Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
Documents | |
MSDS | No |
ProductSpecificationSheet | |
Datasheet | DownloadPDF |
CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchain(14kDa)andacarboxyl-terminalheavychain(34kDa).Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusofthe34kDaheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossiblyAlzheimerdisease.
ProductReferences
1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-Coopman,E.etal.,(2006)CancerLett237,167-179.(General)
2)Liaudet-Coopman,E.etal.,(2006)CancerLett237,167-179.(General)
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发布于 : 2021-09-09
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