TherecombinantST2comprisesa310aminoacidfragment(19-328)correspondingtothe
solubleST2codingsequenceandisexpressedinE.coliwithanamino-terminalhexahistidine
tag.
TheST2geneisamemberoftheIL-1receptorfamily,encodingatransmembraneproteinwitha
structuresimilartoIL-1R1.Asolubleformoftheprotein(ST2)isproducedfromthesamegene
byalternativesplicingandisreportedtobeexpressedinseveralcelltypesincludingfibroblasts
andmastcells.SolubleST2hasbeenreportedtoactasanegativeregulatorofTh2cytokine
productionandelavatedlevelshavebeenreportedinseveraldiseasestatesandconditions
includingasthma,sepsis,andmyocardialinfarction.
Format:liquid
Concentration:0.15mg/mL
Purity:>95%bySDS-PAGE
Storage:Theproteinisstableuntiltheexpirydatewhenstoredat-70°C.Repeatedfreezingand
thawingshouldbeavoided.
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E.coliExpressionSystems.pdf(136.05k)
或者可以过柱纯化,过柱纯化要加一半的佐剂,所以纯化后浓度要高于500ug/ml为宜,否则要增加免疫的次数。
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