Description
MelanostatinisaneuromodulatorypeptideoftheMIF-1family.MelanostatinmodulatesD2receptordopaminesignalinganddownstreameffects.Additionally,thispeptidepotentiatesantidepressantactivityofamitriptylineanddesipramineintheforcedswimtest.
References
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MishraRK,MakmanMH,CostainWJ,etal.ModulationofagoNISTstimulatedadenylylcyclaseandGTPaseactivitybyL-pro-L-leu-glycinamideanditspeptidomimeticanalogueinratstriatalmembranes.NeurosciLett.1999Jul2;269(1):21-4.PMID:10821635.
KostowskiW,DanyszW,DyrW,etal.MIF-1potentiatestheactionoftricyclicantidepressantsinananimalmodelofdepression.Peptides.1991Sep-Oct;12(5):915-8.PMID:1686934.