Cellular morphology, adhesion, and motility occur through dynamic reorganization of actin-based superstructures. Actin-binding proteins are critical for regulating actin polymerization and superstructure formation. The Arp2/3 complex is an actin polymerization-inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. Several nucleation promoting factors, such as WASP and coronin, regulate the activity of the Arp2/3 complex. In addition, the Arp2/3 complex may be regulated by phosphorylation of specific subunits in the complex. Arp2 has two phosphosites, Thr-237 and Thr-238, that are evolutionarily conserved, and are phosphorylated along with Tyr-202 in response to growth factor stimulation. These phosphorylation events may regulate binding to the pointed end of actin filaments, and alanine substitutions of these Arp2 phosphosites inhibit membrane protrusions. Thus, phosphorylation may be another mode of Arp2/3 complex regulation in addition to the activity of nucleation-promoting factors.
References
Soderling, S.H. (2009). Sci Signal. 2(55):pe5 (Review). LeClaire, L.L. et al (2008). J Cell Biol. 182(4):647.Kelleher, J.F. et al. (1995). J Cell Biol. 131(2):385.
Immunocytochemical labeling of Arp3 in aldehyde-fixed and NP-40-permeabilized rat PC12 cells differentiated with NGF. The cells were labeled with rabbit polyclonal anti-Arp3 (C-terminal region) (AP4581) in the absence (left) or presence (right) of blocking peptide (AX4585). The antibody was detected using appropriate secondary antibody conjugated to DyLight® 594.
*For more information, see UniProt Accession P61158
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*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blotmobilities of known proteins with similar MW.
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白蛋白结构已于1975阐明含585氨基酸残基单链肽量66458含17二硫键含糖组体液pH7.4环境白蛋白负离每带200负电荷血浆主要载体许水溶性差物质通与白蛋白结合运输些物质包括胆红素、链脂肪酸（每结合4-6）、胆汁酸盐、前列腺素、类固醇激素、金属离（Cu2+、Ni2+、Ca2+）药物（阿司匹林、青霉素等）
具性激素或药物与白蛋白结合表现其性视其储存形式由于种结合逆性处于态平衡调节些激素药物代谢具重要意义
我想了解人肝细胞分泌白蛋白的过程，包括从基因水平开始，到分泌出胞外整个过程。还有白蛋白的一些参数，像半衰期啊这些，请问哪里可以找到齐全一点的资料？？
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