BiologicalActivity
ActivatorofSUMO-activatingenzyme,E1ligase.IncreasesSERCA2aSUMOylationandactivity,andenhancescontractilityinratcardiomyocytesinvitro.Improvesventricularfunctioninamousemodelofheartdisease.
TechnicalData
| M.Wt | 354.38 |
| Formula | C17H14N4O3S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 862974-25-2 |
| PubChemID | 3236395 |
| InChIKey | FBCSWQRNKAYAGY-UHFFFAOYSA-N |
| Smiles | COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.09 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight354.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.82mL | 14.11mL | 28.22mL |
| 5mM | 0.56mL | 2.82mL | 5.64mL |
| 10mM | 0.28mL | 1.41mL | 2.82mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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