BiologicalActivity
Potent,competitivedualsite(ATP-andpeptide-binding)Srckinaseinhibitor(IC50valuesare44and88nMforSrcandLckrespectively).InhibitsVEGFR2andc-fmsathigherconcentrations(IC50valuesare0.32and30μMrespectively).CanbeusedinparallelwithPP1(Cat.No.1397)andPP2(Cat.No.1407)toinhibitSrcfamilykinases.
CompoundLibraries
SrcI1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 373.4 |
| Formula | C22H19N3O3 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 179248-59-0 |
| PubChemID | 1474853 |
| InChIKey | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| Smiles | COC(C(OC)=C3)=CC1=C3N=CN=C1NC2=CC=C(OC4=CC=CC=C4)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.34 | 100 | |
| ethanol | 1.87 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight373.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.68mL | 13.39mL | 26.78mL |
| 5mM | 0.54mL | 2.68mL | 5.36mL |
| 10mM | 0.27mL | 1.34mL | 2.68mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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