
Product Name | mCRAMP, mouseGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ |
Size | 1 mg |
Catalog # | AS-61305 |
US$ | $283 |
Purity | % Peak Area By HPLC ≥ 95% |
This cathelicidin-related antimicrobial peptide (mCRAMP) is the sole murine cathelicidin. mCRAMP expression in the intestinal tract is restricted to surface epithelial cells in the colon. mCRAMP shows antimicrobial activity against the murine enteric pathogen Citrobacter rodentium and destroys skin Candida albicans. | |
Detailed Information | ![]() ![]() |
Storage | -20°C |
References | Limura, M. et al. J. Immunol. 174, 4901 (2005); Lopez-Garcia, B. et al. J. Invest. Dermatol. 125, 108 (2005). |
Molecular Weight | 3878.7 |
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ | |
Sequence(Three-Letter Code) | H - Gly - Leu - Leu - Arg - Lys - Gly - Gly - Glu - Lys - Ile - Gly - Glu - Lys - Leu - Lys - Lys - Ile - Gly - Gln - Lys - Ile - Lys - Asn - Phe - Phe - Gln - Lys - Leu - Val - Pro - Gln - Pro - Glu - Gln - OH |
Product Citations | Sakoulas, G. et al. (2014). Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med 92, 139. Subramanian, H. et al. (2013). β-Defensins activate human mast cells via Mas-Related Gene X2. J Immunol 191, 345. doi:10.4049/jimmunol.1300023.Kulkarni, MM. et al. (2011). Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.Cell Microbiol 13, 913. doi: 10.1111/j.1462-5822.2011.01589.x.Gregorio, J. et al. (2010). Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207, 2921.Gable, JE. et al. (2009). Fluorescence and UV resonance Raman study of peptide−vVesicle interactions of human cCathelicidin LL-37 and its F6W and F17W mutants Biochem 48, 11264. doi: 10.1021/bi900996q.Schlamadinger, DE. et al. (2009). Toxins and antimicrobial peptides: interactions with membranes.SPIE Proceedings 7397 doi: 10.1117/12.827439.Gryllos, I. et al. (2008). Induction of group A Streptococcus virulence by a human antimicrobial peptide. PNAS 105, 16755. |
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求问:有没有做过微球/凝胶体系的朋友们?就是将微球载入到凝胶中(尤其是水凝胶),这个体系里微球中的药物不是会扩散到凝胶中吗?所以稳定性是怎么解决的啊?
结合物垫在层析时荧光微球在T线前面凝集的现象怎么解决呢,结合物垫增加了吐温和糖的含量还是有这种现象的


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