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ubpbio/VE-821/F8131/25 mg
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VE-821isapotentandselectiveATPcompetitiveinhibitorofataxia-telangiectasiaandRad3-relatedprotein(ATR)withIC50of26nMincell-freeassays,withminimalactivityagainstATM,DNA-PK,andmTOR.ItaugmentsDNAdamageandcelldeathofcancercellsinresponsetorADIation,alsosensitizescancercellstochemotherapy.
AdditionalInformation
ProductName: | VE-821 |
---|---|
AlsoKnownAs: | 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide |
CatalogNo.: | F8131 |
Size: | 25mg |
CAS: | 1232410-49-9 |
Formula: | C18H16N4O3S |
MolecularWeight: | 368.41Da |
Form: | Lyophilizedpowder |
QualityAssurance: | >98%byHPLCandNMR |
Source: | Synthetic |
Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving |
PDFDataSheet: | DownloadPDFdatasheet |
Image(s): | N/A |
ShippingMethod: | Roomtemperatureshipping |
References: | 1.ReaperPM,etal.(2011)NatChemBiol,7(7),428-430. 2.Prevo,R,etal.(2012)CancerBiolTher,13(11)1072-1081. 3.Huntoon,CJ,etal.(2013)CancerRes,73(12)3683-3691. |