BiologicalActivity
RORγtinverseagonist(IC50=460nM);suppressesTh17celldifferentiationandIL17Aexpressioninvitro.DoesnotsuppresstranscriptionofRORα.MinimalactivitydisplayedonERα,LXRαandthyroidhormonereceptors(IC50values>4.4μM).
TechnicalData
| M.Wt | 441.52 |
| Formula | C25H31NO6 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1334526-14-5 |
| PubChemID | 53385590 |
| InChIKey | YEKVAIMYYCZDLI-MCPYQZEQSA-N |
| Smiles | COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight441.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.32mL | 22.65mL |
| 5mM | 0.45mL | 2.26mL | 4.53mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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