BiologicalActivity
PotentandselectiveantagonistforthehumantypeIinterleukin-1(IL-1)receptor(IC50valuesare8nM,>6.7mMand>200mMforhumantypeI,humantypeIIandmurinetypeIIL-1receptorsrespectively).BlocksIL-1-inducedexpressionofICAM-1andE-selectininHUVECsandIL-1βinductionofIL-8inhumandermalfibroblasts.ReducesIL-1β-inducedIL-6productionandexhibitsanti-inflammatoryactivityinvivo.
TechnicalData
| M.Wt | 1895.14 |
| Formula | C96H123N19O22 |
| Sequence | FEWTPGWYQXYALPL (Modifications:Phe-1=N-terminalAc,X-Aze,Leu-15=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 185413-30-3 |
| PubChemID | 90488713 |
| InChIKey | VASLMBMCJADVGR-BRPRRQPRSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlin10%ethanol/PBS |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1895.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.53mL | 2.64mL | 5.28mL |
| 5mM | 0.11mL | 0.53mL | 1.06mL |
| 10mM | 0.05mL | 0.26mL | 0.53mL |
| 50mM | 0.01mL | 0.05mL | 0.11mL |
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