Tocris公司代理生物计划 Tocris Bioscience现货代理,Tocris/CLP 257/5242/50/50 mg,转运体,Tocris,Bio-Techne,,50 mg蚂蚁淘商城

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Tocris/CLP 257/5242/50/50 mg

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Tocris Bioscience

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5242/50

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4000-520-616

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Description:SelectiveKCC2activator

ChemicalName:(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveKCC2K⁺-Cl^-cotransporteractivator(EC₅₀=616nM).ExhibitsselectivityforKCC2overotherKCCfamilymembers,NKCC1andGABA_Areceptors,aswellas55otherreceptors.EnhancesCl^-transportandincreasesKCC2plasmamembraneexpressioninspinalsliceswithreducedKCC2function.Alleviateshypersensitivityinratswithperipheralnerveinjury.

TechnicalData

M.Wt	307.34
Formula	C₁₄H₁₄FN₃O₂S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1181081-71-9
PubChemID	44188931
InChIKey	SKCADXVKQRCWTR-GHXNOFRVSA-N
Smiles	OC1=C(/C=C2/C(N=C(N3CCCCN3)S2)=O)C=CC(F)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	30.73	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight307.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.25mL	16.27mL	32.54mL
5mM	0.65mL	3.25mL	6.51mL
10mM	0.33mL	1.63mL	3.25mL
50mM	0.07mL	0.33mL	0.65mL

ProductDatasheets

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