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Tocris/Cariporide/5358/10/10 mg
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Description:SelectiveNHE1inhibitor;cardioprotectiveandantitumor
AlternativeNames:HOE642
ChemicalName:N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveNa+/H+exchangerisoform1(NHE1)inhibitor(IC50valuesare0.05,3and1000μMforNHE1,NHE3andNHE2respectively).Attenuatesischemia-inducedcardiomyocyteapoptosisinvitro.Reducescardiacarrhythmiainvivo.AlsopromotesapoptosisincancercellsoverexpressingNHE1.Orallyactive.
TechnicalData
M.Wt | 283.35 |
Formula | C12H17N3O3S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 159138-80-4 |
PubChemID | 151172 |
InChIKey | IWXNYAIICFKCTM-UHFFFAOYSA-N |
Smiles | CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.34 | 100 | |
ethanol | 5.67 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight283.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.53mL | 17.65mL | 35.29mL |
5mM | 0.71mL | 3.53mL | 7.06mL |
10mM | 0.35mL | 1.76mL | 3.53mL |
50mM | 0.07mL | 0.35mL | 0.71mL |
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ProductDatasheets
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