Interleukin4(IL-4)isacytokinethatcanleadtodevelopmentofTh2cells.The140kDIL-4Receptor(CD124)isfoundonmanycelltypes,eventhoseofnon-hematopoieticOrigen.Thereceptorisformedfromtwochains:IL-4R(alpha)andtheIL-2Rgammachain(CD132).PrimarysignalingisthroughtheJAK/Stat6pathwayandMAPKs. Contributor: REFERENCES:HintonHJ,WelhamMJ.1999.Cytokine-inducedproteinkinaseBactivationandBadphosphorylationdonotcorrelatewithcellsurvivalofhemopoieticcells.JImmunol15;162(12):7002-9.