PlateletDerivedGrowthFactor(PDGF)playsacriticalroleincellularproliferationanddevelopment.TheBIOLOGicallyactiveformisadimerformedfromtheAandBchains.PDGFisactivetoadifferingdegreedependingonwhichdimerisformed(AA,AB,orBB).ThePDGFReceptor(PDGFR)isalsoadimerandcanformfromthecombinationofthealphaandbetachainsinanyorder(alpha-alpha,alpha-beta,beta-beta).ThePDGFRdimerisonlyformedafterligandbindingsothealpha/betacompositionofthereceptorcanbeinfluencedbytheformofPDGFthatispresent.UponbindingofligandthePDGFRistyrosinephosphorylatedandleadstothephosphorylationofseveralothercellularproteins. Contributor: REFERENCES: