Glutamatergic-mediatednitricoxide(NO)productionoccursviatheN-methyl-D-asparticacid(NMDA)postsynapticdensityprotein95(PSD95)-neuronalnitricoxidesynthase(NOS1)ternarycomplex.TheincreasedintracellularCa2+stimulatestheinteractionofnNOSandcalmodulin(CaM)andthetranslocatonofnNOSfromtheplasmamembranetothecytoplasm.ThedephosphorylationofnNOSbyCalcineurincatalyzestheconversionofargininetocitrullineandnitricoxide(NO),whichturnsonguanylatecyclaseandthevariouscGMPregulatedsignalingpathways. Contributor: REFERENCES:ArundineMetal.NMDAinducesNOS1translocationtothecellmembraneinNGF-differentiatedPC12cells.BrainRes.2003Jun27;976(2):149-158.