资源 | Tocris 生物科学,Tocris/FC 131/4320/1/1 mg
Biological Activity
CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
Technical Data
| M. Wt | 729.84 |
| Formula | C36H47N11O6 |
| Sequence | XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr] |
| Storage | Store at -20°C |
| CAS Number | 606968-52-9 |
| PubChem ID | 5275848 |
| InChI Key | MBXBICVKLVYNKD-QUAHOIDUSA-N |
| Smiles | NC(=N)NCCC[C@@H]1NC(=O)[C@@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CCCNC(N)=N)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 729.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 1.37 mL | 6.85 mL | 13.7 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 10 mM | 0.14 mL | 0.69 mL | 1.37 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.27 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852
Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477 PMID:
Keywords: FC 131, supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Antivirals, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience
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