MyBioSource/Cavy A Disintegrin and Metalloprotease 10 ELISA Kit/MBS028786/96-Strip-Wells-蚂蚁淘商城

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MyBioSource/Cavy A Disintegrin and Metalloprotease 10 ELISA Kit/MBS028786/96-Strip-Wells

2024-04-27


Product Name	A Disintegrin and Metalloprotease 10 (ADAM10), ELISA Kit
Also Known As	Cavy A Disintegrin and Metalloprotease 10 ELISA Kit
Product Gene Name	ADAM10 elisa kit	[Similar Products]
Research Use Only	For Research Use Only. Not for use in diagnostic procedures.
Request for Manual Insert	$\"Request$

Chromosome Location	Chromosome: 15; NC_000015.9 (58888510..59042177, complement). Location: 15q22
OMIM	602192
3D Structure	ModBase 3D Structure for O14672
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Species Reactivity	Cavy
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Assay Type	Sandwich
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Preparation and Storage	Store all reagents at 2-8 degree C
Product Note	Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
Other Notes	Small volumes of ADAM10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for ADAM10 purchase	MBS028786 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 10 (ADAM10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAM10. The ELISA analytical biochemical technique of the MBS028786 kit is based on ADAM10 antibody-ADAM10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAM10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAM10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
NCBI GI #	2393947
NCBI GeneID	102
NCBI Accession #	AAC51766.1	[Other Products]
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UniProt Primary Accession #	O14672	[Other Products]
UniProt Secondary Accession #	Q10742; Q92650	[Other Products]
UniProt Related Accession #	O14672	[Other Products]
Molecular Weight	84,142 Da
NCBI Official Full Name	ADAM10
NCBI Official Synonym Full Names	ADAM metallopeptidase domain 10
NCBI Official Symbol	ADAM10	[Similar Products]
NCBI Official Synonym Symbols	kuz; AD10; MADM; CD156c; HsT18717	[Similar Products]
NCBI Protein Information	disintegrin and metalloproteinase domain-containing protein 10; CDw156; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10
UniProt Protein Name	Disintegrin and metalloproteinase domain-containing protein 10
UniProt Synonym Protein Names	CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease
Protein Family	Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name	ADAM10	[Similar Products]
UniProt Synonym Gene Names	KUZ; MADM; ADAM 10	[Similar Products]
UniProt Entry Name	ADA10_HUMAN
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NCBI Summary for ADAM10	Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
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UniProt Comments for ADAM10	ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at \'76-Ala-\|-Val-77\' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.Protein type: EC 3.4.24.81; Motility/polarity/chemotaxis; Membrane protein, integral; Cell surface; Cell adhesion; Vesicle; ProteaseChromosomal Location of Human Ortholog: 15q22Cellular Component: Golgi apparatus; focal adhesion; cell surface; membrane; intracellular membrane-bound organelle; postsynaptic density; cytoplasm; plasma membrane; integral to membrane; Golgi-associated vesicle; nucleusMolecular Function: integrin binding; protein binding; protein homodimerization activity; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; endopeptidase activity; SH3 domain binding; protein kinase binding; receptor bindingBiological Process: epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; axon guidance; extracellular matrix organization and biogenesis; Notch signaling pathway; in utero embryonic development; membrane protein ectodomain proteolysis; constitutive protein ectodomain proteolysis; Notch receptor processing; negative regulation of cell adhesion; positive regulation of cell growth; protein amino acid phosphorylation; extracellular matrix disassembly; collagen catabolic process; PMA-inducible membrane protein ectodomain proteolysis; monocyte activation; cell-cell signaling; positive regulation of cell proliferation; ephrin receptor signaling pathway; positive regulation of cell migrationDisease: Reticulate Acropigmentation Of Kitamura; Alzheimer Disease 18

Research Articles on ADAM10	1. MiR-144 and Mir-451 negatively regulator the ADAM10 protein expression and may contribute to Alzheimer disease pathogenesis.
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