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Fitzgerald/ISL1 antibody/10R-2056/100 ul

  
  2024-04-28
  

OVERVIEW:

Synonyms Cross Reactivity Applications Immunogen
Monoclonal ISL1 antibody, Anti-ISL1 antibody, ISL-1 antibody, ISL-1 antibody, ISL1, ISL-1, ISL 1 antibody, ISL1 transcription factor antibody, ISL 1, ISL 1 antibody, LIM antibody
Human
ELISA, IF, WB
ISL1 antibody was raised in Mouse using a purified recombinant fragment of human ISL1 expressed in E. coli as the immunogen.

SPECIFICATIONS:

Host Clone Isotype Form & Buffer Concentration
Mouse
1B1
IgG1
Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
1.0 mg/ml

STORAGE & SAFETY:

Storage
Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations
ELISA: 1:10,000, IF: 1:200-1:1000, WB: 1:500-1:2000

GENERAL INFORMATION:

Biological Significance
ISL1 is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. It is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Mutations in this gene have been associated with maturity-onset diabetes of the young.

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