mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of t-cell proliferation间充质干细胞缺乏疗效的治疗实验性自身免疫性神经炎尽管体外抑制t细胞增殖.pdf_淘豆网下载所得到的文件列表mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of t-cell proliferation间充质干细胞缺乏疗效的治疗实验性自身免疫性神经炎尽管体外抑制t细胞增殖.pdfMesenchymal Stem Cells Lack Efficacy in the Treatmentof Experimental Autoimmune Neuritis despite In VitroInhibition of T-Cell Proliferation. .Marija Sajic1 , David P. J. Hunt1,2,4* , Woojin Lee1, D. Alastair S. Compston2, Judith V. Schweimer3,Norman A. Gregson1, Siddharthan Chandran4, h J. Smith11 Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom, 2 Department of Clinical Neurosciences, University ofCambridge, Cambridge, United Kingdom, 3 Department of Neuroimmunology, King’s College London, London, United Kingdom, 4 MRC Centre for Regenerative Medicine,University of Edinburgh, Edinburgh, United KingdomAbstractMesenchymal stem cells have been demonstrated to ameliorate experimental autoimmune encephalomyelitis (EAE), amodel of multiple sclerosis, prompting clinical trials in multiple sclerosis which are currently ongoing. An importantquestion is whether this therapeutic effect generalises to other autoimmune neurological diseases. We performed two trialsof efficacy of MSCs in experimental autoimmune neuritis (EAN) in Lewis (LEW/Han MHsd) rats, a model of humanautoimmune inflammatory neuropathies. No differences between the groups were found in clinical, histological orelectrophysiological e measures. This was despite the ability of mesenchymal stem cells to inhibit proliferation ofCD4+ T-cells in vitro. Therefore the efficacy of MSCs observed in S demyelination models do not necessarilygeneralise to the treatment of other forms of neurological autoimmunity.Citation: Sajic M, Hunt DPJ, Lee W, Compston DAS, Schweimer JV, et al. (2012) Mesenchymal Stem Cells Lack Efficacy in the Treatment of ExperimentalAutoimmune Neuritis despite In Vitro Inhibition of T-Cell Proliferation. PLoS ONE 7(2): e30708. doi:10.1371/journal.pone.0030708Editor: Pablo Villoslada, Institute Biomedical Research August Pi Sunyer (IDIBAPS) - Hospital Clinic of Barcelona, SpainReceived August 26, 2011; Accepted December 21, 2011; Published February 16, 2012Copyright: 2012 Sajic et al. This is an open-access article distributed under the terms of the mons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: DH is funded by a Brain entrance scholarship (Guarantors of Brain) and by the e Trust. KJS is funded by the Medical Research Council, UnitedKingdom, the Multiple Sclerosis Society of Great Britian Northern Ireland, the European Union (FP6 NeuroproMiSe) and the Brain Research Trust. SC is supportedby the National Institute for Health Research Biomedical Research. The funders had no role in study design, data collection and analysis, decision to publish, orpreparation of the manuscript.Competing Interests: The authors have declared that peting interests exist.* E-mail: d内容来自淘豆网www.taodocs.com转载请标明出处.