伯豪客户发表胃癌研究新成果！

在胃癌（GC）发生过程中，DAN甲基化转移酶3A的功能作用机制目前还不是很清楚。在该研究中，研究人员发现外源表达的DNMT3A通过打乱G1/S的转换而促进肝癌的细胞增殖。同时该研究找到了DNMT3A的下游靶基因p18INK4C，异位表达DNMT3A在转录层次抑制了p18INK4C的表达水平。在GC细胞中减弱p18INK4C的表达诱导细胞周期过程，在DNMT3A过表达细胞中重表达p18INK4C可减弱G1/S的转换。深入研究发现，DNMT3A通过直接调控p18INK4C启动子区的甲基化程度来影响其表达。临床GC样本检测发现，癌组织中p18INK4C的甲基化水平明显高于配对癌旁组织，DNMT3A的表达水平与p18INK4C的表达呈负相关。这些发现提出了胃致癌过程的新的见解，也为胃癌治疗提供了潜在的靶标。该研究中DNMT3A下游靶基因筛选表达谱芯片Affymetrix HTA2.0由上海伯豪生物技术有限公司提供。详细内容

2015年10月：上海伯豪客户应用案例精选

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