Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan.-论文-万方医学网
您的账号已在其他设备登录，您当前账号已强迫下线， 如非您本人操作，建议您在会员中心进行密码修改
确定首页>Cell cycle (Georgetown, Tex.)>Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan. Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan.Mitochondria are key players in aging and cell death. It has been suggested that mitochondrial fragmentation, mediated by the Dnm1/Fis1 organelle fission machinery, stimulates aging and cell death. This was based on the observation that Saccharomyces cerevisiae Δdnm1 and Δfis1 mutants show an enhanced lifespan and increased resistance to cell death inducers. However, the Dnm1/Fis1 fission machinery is also required for peroxisome division. Here we analyzed the significance of peroxisome fission in yeast chronological lifespan, using yeast strains in which fission of mitochondria was selectively blocked. Our data indicate that the lifespan extension caused by deletion of FIS1 is mainly due to a defect in peroxisome fission and not caused by a block in mitochondrial fragmentation. These observations are underlined by our observation that deletion of FIS1 does not lead to lifespan extension in yeast peroxisome deficient mutant cells.
更多 a Molecular Cell Biology, Systems Biology Center for Energy Metabolism and Aging; Groningen Biomolecular Sciences and Biotechnology Institute; University of Groningen ; Groningen , The Netherlands.特别提示：本网站仅提供医学学术资源服务，不销售任何药品和器械，有关药品和器械的销售信息，请查阅其他网站。
本文链接： https://www.ebiomall.com/b64-lifespan/info-1512324558.html
暂无品牌问答
