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Abbexa是一家致力于为生命科学研究、药物研发及生物技术公司提供优质抗体、蛋白及检测试剂盒等产品的高科技生物技术公司。基于剑桥大学研发技术优势,Abbexa提供包括一抗、二抗、纯化蛋白、ELISA试剂盒、各种酶类及其它多种试剂与研究工具的大量生命科学研究产品。
目前Abbexa的产品涵盖单克隆抗体、多克隆抗体、纯化蛋白质及生物试剂,此外,为满足研发人员特殊的实验需要,Abbexa还提供抗体/多肽定制服务。严格的质控标准保证了Abbex产品的高性能,如您对产品不满意,Abbexa将直接提供退/换货服务
CLIAKits化学发光免疫分析(chemiluminescenceimmunoassay,CLIA)
RNAInterferenceProductsRNA干扰试剂
RNA干扰(RNAinterference,RNAi)是指在进化过程中高度保守的、由双链RNA(double-strandedRNA,dsRNA)诱发的、同源mRNA高效特异性降解的现象。基因沉默,主要有转录前水平的基因沉默(TGS)和转录后水平的基因沉默(PTGS)两类:TGS是指由于DNA修饰或染色体异染色质化等原因使基因不能正常转录;PTGS是启动了细胞质内靶mRNA序列特异性的降解机制。有时转基因会同时导致TGS和PTGS。
由于使用RNAi技术可以特异性剔除或关闭特定基因的表达,(长度超过三十的dsRNA会引起干扰素毒性)所以该技术已被广泛用于探索基因功能和传染性疾病及恶性肿瘤的治疗领域。
1.RNAi抑制转座子活性
两方面的证据提示转座子活性的抑制与siRNA有关
①发现蠕虫mut-7基因参与RNAi并且与转座子的转座抑制有关;
②在果蝇中,参与RNAi的RNA解螺旋酶Spindle-E的突变将导致该基因引起的基因沉默的缺失,同时提高了反转录转座子活性。
2.RNAi抵御病毒感染
在拟南芥中研究转基因引起基因沉默时发现,sgs2/sde1基因突变的拟南芥对病毒的侵染表现出高度的敏感性。
3.RNAi参与异染色质的形成和维持
Hall等研究表明,着丝粒同源重复序列和RNAi组分一起正负调节着异染色质的形成并共同促使异染色质组装成核;Vople等在敲除裂殖酵母(S.pombe)的RNAi途径基因(如Argonaute、Dicer、RDRP)时发现异染色质转录得到的dsRNA可以在RNAi途径的参与下,加工成siRNA,siRNA募集异染色质蛋白1(HP1),然后靶向性引起相应异染色质区域的转基因沉默。
4.RNAi参与机体的发育调控及生理代谢
RNAi只抑制转录后的基因,所以RNAi在生物体发育学研究中具有优势。Chuang等用RNAi技术进一步证实了AG、CLV3、AP1、PAN等已知功能基因在拟南芥花发育过程中的功能。在RNAi过程中形成的RISC复合物可根据不同情况分别利用siRNA或stRNA行使不同的功能,但最终均导致特定基因沉默。
1,25-DihydroxyvitaminD3(Calcitriol)ELISAKit
abx051035
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$572.75(96tests)ComparisonList1,25-DihydroxyvitaminD3(Calcitriol)ELISAKit
abx156662
QuantitativeCompetitiveRange:24.7pg/ml-2000pg/ml
Sensitivity:<9.13pg/mlUS$812.00(96tests)ComparisonList1,25-DihydroxyvitaminD3(Calcitriol)ELISAKit
abx350730
QuantitativeCompetitiveRange:7.81pg/ml-500pg/ml
Sensitivity:4.69pg/mlUS$572.75(96tests)ComparisonList1,25-DihydroxyvitaminD3(Calcitriol)ELISAKit
abx513030
QuantitativeRange:15.6pg/ml-1000pg/ml
Sensitivity:<3.6pg/mlUS$572.75(96tests)ComparisonList1,3-DipalmitinELISAKit
abx258848
QuantitativeCompetitiveRange:12.35pg/ml-1000pg/ml
Sensitivity:<4.94pg/mlUS$826.50(96tests)ComparisonList1,5-Anhydroglucitol(1,5-AG)ELISAKit
abx150305
QuantitativeCompetitiveRange:1.9µg/ml-150µg/ml
Sensitivity:<0.7µg/mlUS$826.50(96tests)ComparisonList1-Desamino8DArginineVasopressin(DDAVP)ELISAKit
abx150333
QuantitativeCompetitiveRange:123.5pg/ml-10000pg/ml
Sensitivity:<39.5pg/mlUS$826.50(96tests)ComparisonList1-Desamino8DArginineVasopressin(DDAVP)ELISAKit
abx574303
QuantitativeCompetitiveRange:12.35pg/ml-1000pg/ml
Sensitivity:<5.52pg/mlUS$862.75(96tests)ComparisonList11,12-DihydroxyeicosatrienoicAcids(11,12-DiHETrE)ELISAKit
abx352136
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$681.50(96tests)ComparisonList11-DehydrothromboxaneB2(11-Dehydro-TXB2)ELISAKit
abx255672
QuantitativeCompetitiveRange:15.6pg/ml-1000pg/ml
Sensitivity:9.38pg/mlUS$609.00(96tests)ComparisonList11-DehydrothromboxaneB2(11-Dehydro-TXB2)ELISAKit
abx251255
QuantitativeCompetitiveRange:15.6pg/ml-1000pg/ml
Sensitivity:9.38pg/mlUS$652.50(96tests)ComparisonList12-HydroxyeicosatetraenoicAcid(12-HETE)ELISAKit
abx251300
QuantitativeCompetitiveRange:0.78ng/ml-50ng/ml
Sensitivity:0.47ng/mlUS$572.75(96tests)ComparisonList12-HydroxyeicosatetraenoicAcid(12-HETE)ELISAKit
abx258309
QuantitativeCompetitiveRange:12.35ng/ml-1000ng/ml
Sensitivity:<5.45ng/mlUS$826.50(96tests)ComparisonList12-HydroxyeicosatetraenoicAcid(12-HETE)ELISAKit
abx514543
QuantitativeCompetitiveRange:0.156ng/ml-10ng/ml
Sensitivity:0.09ng/mlUS$572.75(96tests)ComparisonList13,14dihydro15ketoProstaglandinF2Alpha(PGFM)ELISAKit
abx352258
QuantitativeCompetitiveRange:0.312ng/ml-20ng/ml
Sensitivity:0.19ng/mlUS$681.50(96tests)ComparisonList14-3-3beta/zetaCellELISAKit
abx595001
Description:14-3-3beta/zetaCellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbeseededonto..US$543.75(96tests)ComparisonList14-3-3ProteinTheta(YWHAQ)ELISAKit
abx153545
QuantitativeSandwichRange:0.312ng/ml-20ng/ml
Sensitivity:<0.13ng/mlUS$797.50(96tests)ComparisonList14-3-3ProteinTheta(YWHAQ)ELISAKit
abx156960
QuantitativeSandwichRange:0.156ng/ml-10ng/ml
Sensitivity:<0.06ng/mlUS$797.50(96tests)ComparisonList14-3-3ProteinZeta/Delta(YWHAZ)ELISAKit
abx258054
QuantitativeSandwichRange:0.312ng/ml-20ng/ml
Sensitivity:<0.12ng/mlUS$797.50(96tests)ComparisonList14-3-3ProteinZeta/Delta(YWHAZ)ELISAKit
abx595002
Description:14-3-3zetaCellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbeseededontoacl..US$543.75(96tests)ComparisonList15-Deoxy-delta12,14-prostaglandinJ2(15d-PGJ2)ELISAKit
abx351111
QuantitativeCompetitiveRange:3.125ng/ml-200ng/ml
Sensitivity:1.88ng/mlUS$282.75(24tests)ComparisonList17-Hydroxyprogesterone(17-OHP)ELISAKit
abx150306
QuantitativeCompetitiveRange:246.9pg/ml-20000pg/ml
Sensitivity:<87.3pg/mlUS$812.00(96tests)ComparisonList17-Hydroxyprogesterone(17-OHP)ELISAKit
abx257402
QuantitativeCompetitiveRange:0.47ng/ml-30ng/ml
Sensitivity:0.28ng/mlUS$572.75(96tests)ComparisonList2,3-Bisphosphoglycerate(2,3-BPG)ELISAKit
abx514494
QuantitativeRange:31.2nmol/ml-2000nmol/ml
US$572.75(96tests)ComparisonList2,3-Bisphosphoglycerate(2,3-BPG)ELISAKit
abx585473
QuantitativeCompetitiveRange:1.23µg/ml-100µg/ml
Sensitivity:<0.46µg/mlUS$855.50(96tests)ComparisonList2-Arachidonoylglycerol(2-AG)ELISAKit
abx258337
QuantitativeCompetitiveRange:3.7ng/ml-300ng/ml
Sensitivity:<1.44ng/mlUS$862.75(96tests)ComparisonList2-Methoxyestradiol(2-ME2)ELISAKit
abx257195
QuantitativeCompetitiveRange:61.25ng/ml-2000ng/ml
Sensitivity:<31ng/mlUS$543.75(96tests)ComparisonList25-HydroxyvitaminD3(Calcidiol)ELISAKit
abx150307
QuantitativeCompetitiveRange:2.47ng/ml-200ng/ml
Sensitivity:<0.91ng/mlUS$812.00(96tests)ComparisonList25-HydroxyvitaminD3(Calcidiol)ELISAKit
abx570015
QuantitativeCompetitiveRange:3.125ng/ml-200ng/ml
Sensitivity:1.88ng/mlUS$572.75(96tests)ComparisonList25-HydroxyvitaminD3(Calcidiol)ELISAKit
abx514367
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$572.75(96tests)ComparisonList26SProteasomeNon-ATPaseRegulatorySubunit2(PSMD2)ELISAKit
abx595823
Description:PSMD2CellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbeseededontoaclearfl..US$543.75(96tests)ComparisonList26SProteasomeRegulatorySubunit6A(PSMC3)ELISAKit
abx595509
Description:26SProteasomeRegulatorySubunit6A(PSMC3)CellELISAKitisacell-basedELISAKit.Cellstobea..US$543.75(96tests)ComparisonList27-Hydroxycholesterol(27-HC)ELISAKit
abx257403
QuantitativeCompetitiveRange:15.625ng/ml-1000ng/ml
Sensitivity:<9.375ng/mlUS$543.75(96tests)ComparisonList3-Methoxytyramine(3-MT)ELISAKit
abx585075
QuantitativeCompetitiveRange:61.7pg/ml-5000pg/ml
Sensitivity:<23.5pg/mlUS$862.75(96tests)ComparisonList3-Methylhistidine(3-MH)ELISAKit
abx257295
QuantitativeCompetitiveRange:6.25nmol/ml-400nmol/ml
Sensitivity:<3.75nmol/mlUS$543.75(96tests)ComparisonList3-Nitrotyrosine(3-NT)ELISAKit
abx257155
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$572.75(96tests)ComparisonList4-Hydroxynonenal(4-HNE)ELISAKit
abx257639
QuantitativeCompetitiveRange:0.625ng/ml-40ng/ml
Sensitivity:0.38ng/mlUS$572.75(96tests)ComparisonList4E-BP1CellELISAKit
abx595006
Description:4E-BP1CellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbeseededontoaclearf..US$543.75(96tests)ComparisonList5-HydroxyeicosatetraenoicAcid(5-HETE)ELISAKit
abx251443
QuantitativeCompetitiveRange:0.156ng/ml-10ng/ml
Sensitivity:<0.09ng/mlUS$572.75(96tests)ComparisonList5-HydroxyeicosatetraenoicAcid(5-HETE)ELISAKit
abx258329
QuantitativeCompetitiveRange:9.88ng/ml-800ng/ml
Sensitivity:<3.93ng/mlUS$826.50(96tests)ComparisonList5-HydroxyindoleaceticAcid(5-HIAA)ELISAKit
abx150308
QuantitativeCompetitiveRange:4.94ng/ml-400ng/ml
Sensitivity:<1.93ng/mlUS$826.50(96tests)ComparisonList5-HydroxyindoleaceticAcid(5-HIAA)ELISAKit
abx257174
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$572.75(96tests)ComparisonList5-Hydroxytryptophan(5-HTP)ELISAKit
abx156752
QuantitativeCompetitiveRange:4.93ng/ml-400ng/ml
Sensitivity:<1.94ng/mlUS$826.50(96tests)ComparisonList53BP1CellELISAKit
abx595007
Description:53BP1CellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbeseededontoaclearfl..US$543.75(96tests)ComparisonList6-Hydroxydopamine(6-OHDA)ELISAKit
abx350007
QuantitativeCompetitiveRange:0.156ng/ml-10ng/ml
Sensitivity:0.1ng/mlUS$543.75(96tests)ComparisonList6-Keto-ProstaglandinF1alpha(6-Keto-PGF1alpha)ELISAKit
abx257166
QuantitativeCompetitiveRange:15.6pg/ml-1000pg/ml
Sensitivity:9.38pg/mlUS$572.75(96tests)ComparisonList60SRibosomalProteinL10(RPL10)ELISAKit
abx595008
Description:60SRibosomalProteinL10CellELISAKitisacell-basedELISAKit.Cellstobeassayedshouldbese..US$543.75(96tests)ComparisonList7-DehydrocholesterolELISAKit
abx150484
QuantitativeCompetitiveRange:2.47ng/ml-200ng/ml
Sensitivity:<0.94ng/mlUS$797.50(96tests)ComparisonList8-Hydroxy-2\'-Deoxyguanosine(8-OHdG)ELISAKit
abx150312
QuantitativeCompetitiveRange:74.1pg/ml-6000pg/ml
Sensitivity:<26.29pg/mlUS$812.00(96tests)ComparisonList8-Hydroxy-2\'-Deoxyguanosine(8-OHdG)ELISAKit
abx257146
QuantitativeCompetitiveRange:1.56ng/ml-100ng/ml
Sensitivity:0.94ng/mlUS$572.75(96tests)ComparisonList