索取文献 | Tocris 生物科学,Tocris/ATI 2341/5795/1/1 mg-蚂蚁淘生物

Description: CXCR4 allosteric agonist Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

CXCR4 allosteric agonist (EC₅₀ = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards G_i proteins over G₁₃ and β-arrestin.

Technical Data

M. Wt	2256.82
Formula	C₁₀₄H₁₇₈N₂₆O₂₅S₂
Sequence	MGYQKKLRSMTDKYRL (Modifications: Met-1 = N-terminal Palmitoyl)
Storage	Store at -20°C
CAS Number	1337878-62-2
PubChem ID	101961246
InChI Key	YMLOFEANRZSEGQ-QNHYGVTPSA-N
Smiles	CCCCCCCCCCCCCCCC(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2256.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	0.44 mL	2.22 mL	4.43 mL
5 mM	0.09 mL	0.44 mL	0.89 mL
10 mM	0.04 mL	0.22 mL	0.44 mL
50 mM	0.01 mL	0.04 mL	0.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255 PMID: 21139054

Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1 PMID: 26080355

Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088 PMID: 24309376

Keywords: ATI 2341, supplier, CXCR4, allosteric, agonists, polymorphonuclear, neutrophils, PMNs, hematopoietic, stem, progenitor, cells, HSPCs, biased, signaling, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience