西格玛受体 |其他药理学 | Tocris 生物科学,Tocris/UC 112/5251/10/10 mg-蚂蚁淘生物

Description: IAP and XIAP inhibitor; antitumor Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

IAP inhibitor (IC₅₀ values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.

Compound Libraries

UC 112 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	348.44
Formula	C₂₂H₂₄N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	383392-66-3
PubChem ID	3426979
InChI Key	LTGLGIQQZXSLLF-UHFFFAOYSA-N
Smiles	OC1=C3C(C=CC=N3)=C(COCC4=CC=CC=C4)C=C1CN2CCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	34.84	100
ethanol	6.97	20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 348.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.87 mL	14.35 mL	28.7 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Wang Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J.Pharmacol.Exp.Ther. 349 319 PMID: 24623800

Keywords: UC 112, supplier, UC112, inhibitors, inhibits, apoptosis, proteins, antitumor, multidrug, resistant, caspase, apoptosis, Inhibitor, of, Apoptosis, (IAP), Inhibitor, of, Apoptosis, (IAP), Tocris Bioscience