Product overview

• NameCyclopiazonic acid
• Short descriptionPotent SERCA1a inhibitor
• Biological descriptionPotent sarcoplasmic reticulum Ca²⁺ -ATPase 1a (SERCA1a) inhibitor. Also inhibits cell proliferation but is 40 times less potent than ochratoxin A (approx IC₅₀ = 52 µM).
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical name(6aR,11aS,11bR)-rel-10-Acetyl-2,6,6 a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1,2: 2,3]isoindolo[4,5,6-cd]indol-9-one
• Molecular Weight336.39
• Chemical structure
• Molecular FormulaC₂₀H₂₀N₂O₃
• CAS Number18172-33-3
• PubChem identifier54682463
• SMILESCC(=O)C1=C([C@@H]2[C@@H]3[C@@H](CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O
• InChiInChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,24H,7H2,1-3H3/t12-,16+,17+/m1/s1
• InChiKeySZINUGQCTHLQAZ-DQYPLSBCSA-N
• MDL numberMFCD00167445

Storing and Using Your Product

• Storage instructions-20°C
• Solubility overviewSoluble in ethanol (5mM) or DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cyclopiazonic acid

• Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+-ATPases.

  Kotšubei A et al (2013)FEBS J 280(21) : 5441-9. PubMedID: 23621633

• The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes.

  Keblys M et al (2004)Mycopathologia 158(3) : 317-24. PubMedID: 15702270