Tocris/TC-G 1004/4407/50/50 mg-蚂蚁淘生物

Description: Potent and selective A_2A antagonist Chemical Name: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent antagonist of adenosine A_2A receptors; displays >100-fold selectivity for A_2A over A₁ receptors (K_i values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats.

Compound Libraries

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Technical Data

M. Wt	421.5
Formula	C₂₂H₂₇N₇O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1061747-72-5
PubChem ID	25074316
InChI Key	JENSDTKXNVHSSN-UHFFFAOYSA-N
Smiles	CC1=CC(C)=NN1C2=NC(C3=CC=CC(N4CCC(OC)CC4)=N3)=CC(NC(C)=O)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

1eq. HCl	42.15	100
DMSO	42.15	100
ethanol	42.15	100

Preparing Stock Solutions

The following data is based on the product molecular weight 421.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.19 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Zhang et al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A_2A adenosine receptor antagonists for the treatment of Parkinson\'s disease. J.Med.Chem. 51 7099 PMID: 18947224

Keywords: TC-G 1004, supplier, TC-G1004, adenosine, A2A, receptors, selective, potent, antagonists, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience