- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Cilostazol is a quinolone inhibitor of phosphodiesterase 3B (PDE 3B) that exhibits vasodilatory, antiplatelet, anti-inflammatory, anti-diabetic, antidepressant, anxiolytic, and pro-angiogenic activities. Cilostazol is clinically used to treat intermittent claudication associated with peripheral vascular disease. Cilostazol decreases production of TNF-α in macrophages and inhibits TNF-α-induced inflammation in adipose tissue, improving glucose tolerance and insulin resistance in vivo. Additionally, cilostazol decreases immobility time in the forced swim test and burying activity in the marble burying test. In other animal models, this compound upregulates production of G-CSF and VEGF, inducing angiogenesis.
Product Info
73963-72-1 |
≥98% |
C20H27N5O2 |
369.46 |
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone |
6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one |
OPC-13013; Pletal |
159.4-160.3°C |
Soluble in acetic acid, chloroform, and DMSO. Practically insoluble in water and ether. |
White to off white powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
C3246 Info Sheet PDF |
References
Biscetti F, Pecorini G, Straface G, et al. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. Int J Cardiol. 2013 Aug 10;167(3):910-6. PMID: 22473072.
Wada T, Onogi Y, Kimura Y, et al. Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions. Eur J Pharmacol. 2013 May 5;707(1-3):120-9. PMID: 23528355.
Patel DS, Anand IS, Bhatt PA. Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - cilostazol. Indian J Psychol Med. 2012 Apr;34(2):124-8. PMID: 23162186.
