General Information

Product

P2Y12 Antibody

Description

P2Y purinoceptor 12 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chimpanzee, Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 320-370 on human P2Y12 protein.

Accession #

NCBI: NP_795345.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9H224

Overview

Serves as a receptor for ADP and ATP that is coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. It is necessary for platelet aggregation and blood coagulation.

Molecular Function

G-protein coupled receptor, Transducer, ADP-receptor activity

Subcellular Location

Cell membrane; Multipass membrane protein

Expression

It is highly expressed in the platelets with lower levels of expression found in the brain, and is also expressed in the spinal cord and fetal brain. The lowest levels of expression are found in the lung, appendix, pituitary and adrenal gland.

Alternative Nomenclature

ADP glucose receptor antibody

ADPG R antibody

ADPGR antibody

BDPLT8 antibody

G protein coupled receptor SP1999 antibody

Gi coupled ADP receptor HORK 3 antibody

HORK 3 antibody

P2RY 12 antibody

P2T(AC) antibody

P2Y 12 antibody

P2Y purinoceptor 12 antibody

P2Y(ADP) antibody

P2Y(cyc) antibody

P2Y12 antibody

P2Y12 platelet ADP receptor antibody

Platelet ADP receptor antibody

Purinergic receptor P2RY12 antibody

Purinergic receptor P2Y G protein coupled 12 antibody

Purinergic receptor P2Y12 antibody

Putative G protein coupled receptor antibody

SP 1999 antibody