Adipogen/Nargenicin A<sub>1</sub>/BVT-0204-M001/1 mg
More Information Product Details
Synonyms | CP-47,444; CS682 |
Product Type | Chemical |
Properties
Formula | C28H37NO8 |
MW | 515.6 |
CAS | 70695-02-2 |
Source/Host Chemicals | Isolated from Actinomyces sp. Gö301. |
Purity Chemicals | ≥98% (HPLC) |
Appearance | Off-white powder. |
Solubility | Soluble in DMSO or methanol. |
Identity | Determined by 1H-NMR. |
Declaration | Manufactured by BioViotica. |
InChi Key | YEUSSARNQQYBKH-SIMZXIQRSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C.After reconstitution protect from light at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia.
- More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin.
- Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA.
- Displays low cytotoxicity compared to erythromycin and spiramycin.
Product References
Structure of natural antibiotic CP-47,444: W.D. Celmer et al., J. Am. Chem. Soc. 102, 4203-4209 (1980).9-O-Esters of nodusmicin: B.J. Magerlein and S.A. Mizsak, J. Antibiot. 35, 111-112 (1981).Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1: D.E. Cane and C. Yang, J. Am. Chem. Soc. 106, 784-787 (1984).Biosynthesis of nargenicin and nodusmicin: W.C. Snyder and K.L. Rinehart, jr., J. Am. Chem. Soc. 106, 787-789 (1984).Nargenicin biosynthesis: D.E. Cane et al., J. Am. Chem. Soc. 115, 527-535 (1993).The chemistry of the Nargenicin macrolides: J. Kallmerten, in Studies in natural products chemistry (Ed.: A.-U. Rahman, Elsevier)17, 283-310 (1995).Production, isolation and biological activity of nargenicin from Nocardia sp. CS682: J.K. Sohng et al., Arch. Pharm. Res. 31, 1339-1345 (2008).Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by HPLC: S.S. Cho et al., Arch. Pharm. Res. 32, 335-340 (2009).Nargenicin attenuates lipopolysaccharide-induced responses in BV-2 cells: J.C. Yoo et al., Neuroreport 20, 1007 (2009).Nargenicin enhances 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced leukemia cell differentiation via PKCbetal/MAPK pathways: S.H. Kim et al., Biochemical Pharmacology 77, 1694-1701 (2009).
