Adipogen/Pioglitazone/AG-CR1-0067-M025/25 mg
More Information Product Details
Synonyms | 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl-2,4-thiazolidinedione |
Product Type | Chemical |
Properties
Formula | C19H20N2O3S |
MW | 356.4 |
Merck Index | 14: 7452 |
CAS | 111025-46-8 |
Purity Chemicals | ≥98% (1H-NMR). |
Appearance | White to off-white solid. |
Solubility | Soluble in DMSO (2.5 mg/ml) or dimethylformamide (DMF) (2.5 mg/ml). |
Identity | Determined by 1H-NMR. |
InChi Key | HYAFETHFCAUJAY-UHFFFAOYSA-N |
Shipping and Handling
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Thiazolidinedione (TZD) reference compound [2, 3].
- Selective PPARγ agonist.Selectively activates PPARγ-1 [1, 3].
- Anti-diabetic [3-5], decreasing insulin resistance in adipose tissue.
- Is about one tenth as potent as rosiglitazone [1, 2].
- Lipid metabolism modulator [6].
- Estrogen synthesis inhibitor [7].
- NF-κB inhibitor [8].
- Neuroprotective [9].
Product References
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone: J. Sakamoto, et al.; BBRC 278, 704 (2000)The PPARs: from orphan receptors to drug discovery: T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000)The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995)[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)Pioglitazone: beyond glucose control: P. de Pablos-Velasco; Expert Rev. Cardiovasc. Ther. 8, 1057 (2010) ReviewRosiglitazone and Pioglitazone Inhibit Estrogen Synthesis in Human Granulosa Cells by Interfering with Androgen Binding to Aromatase: D. Seto-Young, et al.; Horm. Metab. Res. 43, 250 (2011)Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-kappaB: C. Ao, et al.; Cell Biol. Int. 34, 723 (2010)Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway: H.L. Zhang, et al.; Neuroscience 176, 381 (2011)Wnt/b-catenin signaling modulates human airway sensitization induced by b2-adrenoceptor stimulation: C. Faisy, et al.; PLoS One 9, e111350 (2014)
