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Adipogen/Pioglitazone/AG-CR1-0067-M025/25 mg
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5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl-2,4-thiazolidinedione
Chemical
C19H20N2O3S
356.4
14: 7452
111025-46-8
≥98% (1H-NMR).
White to off-white solid.
Soluble in DMSO (2.5 mg/ml) or dimethylformamide (DMF) (2.5 mg/ml).
Determined by 1H-NMR.
HYAFETHFCAUJAY-UHFFFAOYSA-N
BLUE ICE
+4°C
-20°C
Protect from light.
Stable for at least 2 years after receipt when stored at -20°C.
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  • Thiazolidinedione (TZD) reference compound [2, 3].
  • Selective PPARγ agonist.Selectively activates PPARγ-1 [1, 3].
  • Anti-diabetic [3-5], decreasing insulin resistance in adipose tissue.
  • Is about one tenth as potent as rosiglitazone [1, 2].
  • Lipid metabolism modulator [6].
  • Estrogen synthesis inhibitor [7].
  • NF-κB inhibitor [8].
  • Neuroprotective [9].
Product References
  • Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone: J. Sakamoto, et al.; BBRC 278, 704 (2000)
  • The PPARs: from orphan receptors to drug discovery: T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000)
  • The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996)
  • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995)
  • [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994)
  • Pioglitazone: beyond glucose control: P. de Pablos-Velasco; Expert Rev. Cardiovasc. Ther. 8, 1057 (2010) Review
  • Rosiglitazone and Pioglitazone Inhibit Estrogen Synthesis in Human Granulosa Cells by Interfering with Androgen Binding to Aromatase: D. Seto-Young, et al.; Horm. Metab. Res. 43, 250 (2011)
  • Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-kappaB: C. Ao, et al.; Cell Biol. Int. 34, 723 (2010)
  • Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway: H.L. Zhang, et al.; Neuroscience 176, 381 (2011)
  • Wnt/b-catenin signaling modulates human airway sensitization induced by b2-adrenoceptor stimulation: C. Faisy, et al.; PLoS One 9, e111350 (2014)