Description: H₁/ H₂ agonist Alternative Names: Histamine trifluoromethyl toluidide Chemical Name: 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

H₁ and H₂ receptor agonist. 4x10⁴ times more active than histamine in H₂-mediated effects in natural suppressor cells. Increases intracellular Ca²⁺ and IP₃ in lymphocytes through a binding site other than H₁, H₂ or H₃.

Technical Data

M. Wt	614.57
Formula	C19H25F3N4O.2C4H4O4
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	195867-54-0
PubChem ID	45073433
InChI Key	ODAOZWTYNWZSBY-SPIKMXEPSA-N
Smiles	[H]OC(=O)C=C/C(=O)O[H].[H]OC(=O)C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	61.46	100
water	61.46	100

Preparing Stock Solutions

The following data is based on the product molecular weight 614.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.63 mL	8.14 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308 PMID: 3011908

Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115 PMID: 2959777

Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9 PMID:

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Keywords: HTMT dimaleate, supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, Histamine, trifluoromethyl, toluidide, Histamine, H1, Receptors, Histamine, H2, Receptors, Histamine, H1, Receptors, Tocris Bioscience