| 货号： | WL02237 |
| 抗体名： | BECN1/Beclin1 抗体 |
| 抗体英文名： | BECN1/Beclin1 antibody |
| 浓度： | >1mg/ml |
| 应用范围： | WB，IHC |
| 宿主： | 兔 |
| 适应物种： | H，M，R |
| 标记物： | 无 |
| 克隆性： | 否 |
| 保存条件： | -20℃ |
| 形态： | 液体 |
| 亚型： | IgG |
| 规格： | 50μl(>50μg) |
本公司所有一抗，50μl(>50μg)现价450元/支，全部现货，均提供20μl免费试用装，详情请点击免费试用 | 产品货号 | WL02237 | | 产品名称 | BECN1/Beclin1 Antibody | | 预测分子量 | 60kDa | | 别名 | ATG6; VPS30; beclin1 | | 浓度 | ＞1 mg/ml | | 免疫原 | 合成BECN1/Beclin1多肽 | | 抗体来源 | 兔 | | 特异性 | 抗人，小鼠，大鼠 | | 克隆类型 | 多克隆抗体 | | 产品应用 | WB;IHC | | 成分 | 亲和纯化抗体，20 mM PBS，150 mM NaCl，100 μg/ml BSA，50%甘油，NaN3<0.02% | | 保存条件 | -20℃保存 | | 背景资料 | Beclin 1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Beclin 1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions . One of the proteins critical to this process is Beclin 1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30. Mammalian Beclin 1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak. | | | | | | | | | | | | | | |
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