Product overview

• NameKC 12291 hydrochloride
• Short descriptionAtypical voltage-gated sodium channel blocker
• Biological descriptionAtypical voltage-gated sodium channel blocker. Reduces sustained Na⁺ channel current and inhibits peak current. Inhibits veratridine- and LPC-induced sustained sodium current contractures (IC₅₀ values are 0.55 and 0.79 µM respectively). Shows cardioprotective, antiischemic and bradycardic actions.
• Biological actionBlocker
• Purity>97%
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Properties

• Chemical name3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride
• Molecular Weight449.99
• Chemical structure
• Molecular FormulaC₂₂H₂₇N₃O₃S.HCl
• CAS Number181936-98-1

Storing and Using Your Product

• Storage instructions+4°C (desiccate)
• Solubility overviewsoluble in water (25mM) or DMSO (50mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for KC 12291 hydrochloride

• KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties.

  John GW et al (2004)Cardiovasc Drug Rev 22(1) : 17-26. PubMedID: 14978516

• Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.

  Létienne R et al (2006)Eur J Pharmacol 530(3) : 243-9. PubMedID: 16368090

• Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels.

  Tamareille S et al (2002)J Cardiovasc Pharmacol 40(3) : 346-55. PubMedID: 12198320