Product overview

• NameFPA 124
• Short descriptionAkt inhibitor
• Biological descriptionAkt (PKB) inhibitor (IC₅₀ = 100 nM ). Inactivates NF-κB. Shows anti-proliferative actions.
• Biological actionInhibitor
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Properties

• Chemical nameDichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamidecoppercomplex
• Molecular Weight381.73
• Chemical structure
• Molecular FormulaC₁₁H₉Cl₂CuN₃O₂S
• CAS Number902779-59-3

Storing and Using Your Product

• Storage instructions+4°C
• Solubility overviewsoluble in DMSO (10mM) or ethanol (10mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for FPA 124

• Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.

  Barve V et al (2006)J Med Chem 49(13) : 3800-8. PubMedID: 16789737

• Activation of protein kinase B/Akt by alpha1-adrenoceptors in the human prostate.

  Strittmatter F et al (2012)Life Sci 90(11-12) : 446-53. PubMedID: 22280833