More Information Product Details Synonyms Product Type Properties Source/Host Sequence Crossreactivity MW Purity Endotoxin Content Concentration Reconstitution Formulation Other Product Data Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet

Interleukin-38; Interleukin-1 Family Member 10; IL-1F10

Protein

E. coli

Human IL-38 (aa Leu20-Trp152) is fused at the C-terminus to a His-tag.

Human

~16kDa

≥95% (SDS-PAGE)

After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1 mg/ml

Reconstitute with 100μl sterile water.

Lyophilized. Contains PBS.

Uni-Prot link Q8WWZ1: Interleukin-38

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

Download PDF

Download PDF

IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.Product References

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses: J. Mora, et al.; J. Mol. Cell Biol. (Epub ahead of print) (2016)