Product overview

• NameIsradipine
• Short descriptionL-type voltage gated calcium channel blocker
• Biological descriptionL-type voltage gated calcium channel blocker (EC₅₀ = 1.4 nM). Highest affinity for Ca_v1.3 and Ca_v1.2 channels over Ca_v1.4. Displays neuroprotective properties. Blood brain barrier permeable.
• Biological actionBlocker
• Purity>99%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical name4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
• Molecular Weight371.39
• Chemical structure
• Molecular FormulaC₁₉H₂₁N₃O₅
• CAS Number75695-93-1
• PubChem identifier3784
• SMILESCC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
• InChiInChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
• InChiKeyHMJIYCCIJYRONP-UHFFFAOYSA-N
• MDL numberMFCD00153820
• AppearanceYellow solid

Storing and Using Your Product

• Storage instructionsroom temperature
• Solubility overviewsoluble in DMSO (50mM) or ethanol (20mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Isradipine

• The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinsons disease.

  Ilijic E et al (2011)Neurobiol Dis 43(2) : 364-71. PubMedID: 21515375

• Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.

  Sinnegger-Brauns MJ et al (2009)Mol Pharmacol 75(2) : 407-14. PubMedID: 19029287

• L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimers disease.

  Anekonda TS et al (2011)Neurobiol Dis 41(1) : 62-70. PubMedID: 20816785

• PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.

  Hof RP et al (1984)J Cardiovasc Pharmacol 6(3) : 399-406. PubMedID: 6202964