Tocris/VUF 5681 dihydrobromide/2493/10/10 mg-蚂蚁淘生物

Description: Potent H₃ receptor silent antagonist Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent histamine H₃ receptor silent antagonist (pK_i = 8.35).

Technical Data

M. Wt	355.11
Formula	C₁₁H₁₉N₃.2HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	639089-06-8
PubChem ID	53440140
InChI Key	YFFVIGXPKWSZHW-UHFFFAOYSA-N
Smiles	Br.Br.C(CC1CCNCC1)CC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	35.51	100
water	35.51	100

Preparing Stock Solutions

The following data is based on the product molecular weight 355.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.82 mL	14.08 mL	28.16 mL
5 mM	0.56 mL	2.82 mL	5.63 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H₃ receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383

Leurs et al (2005) The histamine H3 receptor: from gene cloning to H₃ receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857

Moreno-Delgado et al (2006) Constitutive activity of H₃ autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092

Keywords: VUF 5681 dihydrobromide, supplier, Potent, H3, receptor, silent, antagonists, Receptors, Histamine, histaminergic, VUF5681, dihydrobromide, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience