- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Topotecan is an anticancer chemotherapeutic compound that inhibits topoisomerase I and is clinically used to treat various cancers. Topotecan induces apoptosis in retinocytoma cells and ovarian cancer cells.
Product Info
119413-54-6 |
≥98% |
C23H25N3O5 • HCl |
457.91 |
(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9- dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]- quinoline-3,14(4H,12H)-dione hydrochloride |
Hycamtin; NSC-609669; SKF-104864A |
213-218°C(dec.) |
Soluble in methanol, water (92 mg/ml at 25 °C), DMSO (92 mg/ml at 25 °C), ethanol ( |
Pale Yellow Crystal Powder |
Shipping and Storage
Ambient |
Ambient |
Downloads
T5761 MSDS PDF |
T5761 Info Sheet PDF |
References
Attia SM, Ahmad SF, Abd-Ellah MF, et al. Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 2013 Dec;62:470-4. PMID: 24036143.
Zhang M, Shan BE, Yuan NF, et al. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chin Med J (Engl). 2013 Jan;126(2):340-4. PMID: 23324287.
Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.
Sonabend AM, Stuart RM, Yun J, et al. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump. Neuro Oncol. 2011 Aug;13(8):886-893. PMID: 21750007.
