Biological Activity
Breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.
Technical Data
| M. Wt | 346.6 |
| Formula | C13H10Cl3N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1378872-36-6 |
| PubChem ID | 90488975 |
| InChI Key | WOCCOXNODBCCGK-UHFFFAOYSA-N |
| Smiles | ClC1=C(OCC(N/N=C/C2=CC=CN2)=O)C(Cl)=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 34.66 | 100 |
| ethanol | 17.33 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 346.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 2.89 mL | 14.43 mL | 28.85 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204 PMID: 22941295
Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571 PMID: 22503247
Keywords: ML 239, supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Cancer, Stem, Cells, Cancer, Stem, Cells, Tocris Bioscience
