Tocris/NSC 146109 hydrochloride/2185/50/50 mg-蚂蚁淘生物

Description: Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription Chemical Name: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

Technical Data

M. Wt	316.85
Formula	C₁₇H₁₆N₂S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	59474-01-0
PubChem ID	5458312
InChI Key	VIBMUYOXJUCEMA-UHFFFAOYSA-N
Smiles	N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	31.68	100
ethanol	3.17	10

Preparing Stock Solutions

The following data is based on the product molecular weight 316.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.16 mL	15.78 mL	31.56 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701 PMID: 15729694

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