Application: | ELISA |
Areas of Research: | Immunology & Inflammation |
Clonality: | Polyclonal |
Conjugate: | Biotin |
Host: | Rabbit |
Isotype: | IgG |
Purification: | >95%, Protein G Purified |
Reactivity: | Human |
100% Guarantee: | 6 months |
BackgroundAtypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P. vivax and P. knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
DescriptionACKR1 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ16570
Purification>95%, Protein G purified
ImmunogenRecombinant human Atypical chemokine receptor 1 protein (1-63AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesAtypical chemokine receptor 1, Duffy antigen/chemokine receptor, Glycoprotein D, Plasmodium vivax receptor, ACKR1, DARC, FY, GPD
ApplicationELISA
VCU0006