Tocris/Clobenpropit dihydrobromide/0752/50/50 mg-蚂蚁淘生物

Description: Highly potent H₃ antagonist and H₄ partial agonist Alternative Names: VUF 9153 Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

An extremely potent histamine H₃ antagonist/inverse agonist (pA₂=9.93). Also displays partial agonist activity at H₄ receptors; induces eosinophil shape change with an EC₅₀ of 3 nM. Also available as part of the Histamine H₃ Receptor Tocriset™.

Licensing Information

Sold with the permission of SCI, Amsterdam

Technical Data

M. Wt	470.65
Formula	C₁₄H₁₇ClN₄S.2HBr
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	145231-35-2
PubChem ID	11213569
InChI Key	JIJQPEZAVLJZBO-UHFFFAOYSA-N
Smiles	Br.Br.ClC1=CC=C(CNC(=N)SCCCC2=CNC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 470.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H₄ receptor. Br.J.Pharmacol. 140 1117 PMID: 14530216

Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H₄) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434

Yokoyama et al (1994) Clobenpropit (VUF-9153), a new histamine H₃ receptor antagonist, inhibits electrically induced convulsions in mice. Eur.J.Pharmacol. 260 23 PMID: 7957622

Van der Goot et al (1992) Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H₃ receptor. Eur.J.Med.Chem. 27 511 PMID:

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