More Information Product Details
Synonyms | PD-0332991 |
Product Type | Chemical |
Properties
Formula | C24H29N7O2 . C2H6O4S |
MW | 447.5 . 126.1 |
CAS | 827022-33-3 |
Purity Chemicals | ≥95% |
Appearance | Solid. |
Solubility | Soluble in DMSO or ethanol. |
Declaration | Manufactured by SynKinase. |
Other Product Data | Target: Abl - CDK2 - CDK4 - CDK5 - CDK7 | Kinase Group: PTK | Substrate: TyrosineClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet. |
InChi Key | LYYVFHRFIJKPOV-UHFFFAOYSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC(50) values of 11nM and 16nM, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR.Product References
PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity: J.E. Logan, et al.; Anticancer Res. 33, 2997 (2013)
