product data sheet

Catalog No.: 1133

Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of the kidney and the enteric nervous system.

Physiological responses to GDNF require the presence of a novel glycosylphosphatidylinositol linked protein, GDNFRα, a cell surface receptor for GDNF. The cDNAs encoding GDNFRα from human, rat, chicken, and mouse have been cloned. GDNFRα has also been referred to as GFRα-1, Ret ligand 1 (RETL1) and TGF- β-related neurotrophic factor receptor 1 (TmR1). GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα, and the Ret PTK form a complex to transmit the GDNF signal and to mediate GDNF function. GFRα-1 has been identified in brain, liver, kidney, and spleen.

Antigen: Peptide corresponding to aa 369- 382 of human GFRα-1. This peptide sequence is identical to those of mouse and rat.

Host Species: Rabbit

Stabilizers: None

Preservatives: 0.02% sodium azide.

This antibody recognizes human, mouse, and rat GFRα-1 (approx. 50 kD).

Immunoblotting: use at 1:500 dilution.

Dilute in PBS or medium which is identical to that used in the assay system.

This antibody is stable for at least one (1) year at -20oC. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

QED Bioscience, Inc. 10919 Technology Place, Suite C

San Diego, CA 92127

Toll Free 800.929.2114

Phone 858.675.2405

Fax 858.592.1509

info@qedbio.com

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