MW: 324.4 Da CAS Registry #: 934162-61-5 Formula: C₁₈H₁₇FN₄O Target: PARP1,PARP2 Background:A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Ki of 1 nM and an EC50 of 1 nM in a whole cell assay. A-966492 significantly enhances the efficacy of TMZ in a dose-dependent manner. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood?brain barrier, and appears to distribute into tumor tissue. A-966492 represents a promising, structurally diverse benzimidazole analogue and is being further characterized preclinically. Description:A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. Synonym(s): 2-[2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl]-1H-benzimidazole-4-carboxamide Purity:

≥98% by HPLC

Solubility: Soluble in DMSO 65 mg/ml,Water <1 mg/ml,Ethanol <1 mg/ml Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s): Penning TD, et al. J Med Chem. 2010 Apr 22;53(8):3142-53. Scientific Category: PARP Inhibitor Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.