- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Formoterol is a long-acting β2-adrenergic receptor agonist that is clinically used to treat asthma and chronic obstructive pulmonary disease (COPD). Formoterol exhibits bronchodilatory, anti-asthma, and anti-obesity activities. In a clinical setting, formoterol increases resting energy expenditure, fat utilization, and mitochondrial biogenesis; it also increases mitochondrial expression of NADH dehydrogenase and ATP synthase.
Product Info
183814-30-4 |
≥98% |
(C19H24N2O4)2 • C4H4O4 • 2H2O |
840.91 |
rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4- methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]- formamide fumarate dihydrate |
(E)-but-2-enedioicacid;N-[2-hydroxy-5-[(1S)-1-hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide |
Formoterol Fumarate Dihydrate; Atock; Foradil; Oxeze |
138-140°C |
White to off white powder |
Shipping and Storage
-20°C |
Ambient |
Downloads
F5868 MSDS PDF |
F5868 Info Sheet PDF |
References
Lee P, Day RO, Greenfield JR, et al. Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men. Int J Obes (Lond). 2013 Apr;37(4):593-7. PMID: 22641064.
Wills LP, Trager RE, Beeson GC, et al. The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis. J Pharmacol Exp Ther. 2012 Jul;342(1):106-18. PMID: 22490378.
Rider CF, King EM, Holden NS, et al. Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. PMID: 21622733.
