Product Description
RU58841 is a nonsteroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) comparable to hydroxyflutamide. In competition studies, RU58841 suppresses dihydroxytestosterone (DHT) effects in PC3 cells with the wt AR in dose dependent manner, indicating antagonistic properties. [1]Animal studies in the stumptailed macaque have shown that RU58841 has a dramatic effect on hair regrowth suggesting that it antagonizes testosterone-elicited follicular cell growth inhibition. [2]
Technical information:
| Chemical Formula: | C17H18F3N3O3 | |
| CAS #: | 154992-24-2 | |
| Molecular Weight: | 369.34 | |
| Purity: | >98% | |
| Appearance: | White | |
| Chemical Name: | (Benzonitrile,4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-) | |
| Solubility: | Up to 22 mM in DMSO | |
| Synonyms: | RU-58841, RU58841 |
Shipping Condition: The product is shipped in a glass vial at ambient temperature. Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Pan et al., Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine 1998, 9(1), 39-43. Pubmed ID: 9798729 |
| 2. | Obana et al., Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology 1997, 138(1), 356-361. Pubmed ID: 8977424 |
