Description: Potent and selective A_2B inverse agonist Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide Purity: ≥96% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent and selective adenosine A_2B receptor inverse agonist (K_i values are 1.39, 157, 112 and 230 nM for human A_2B, A₁, A_2A and A₃ receptors respectively).

Licensing Information

Manufactured and sold under license from Adenosine Therapeutics, LLC

Technical Data

M. Wt	503.56
Formula	C27H29N5O5
Storage	Store at +4°C
Purity	≥96% (HPLC)
CAS Number	264622-53-9
PubChem ID	5139184
InChI Key	ZKUCFFYOQOJLGT-UHFFFAOYSA-N
Smiles	O=C(C(NC(C3=CC=C(OCC(NC4=CC=C(C(C)=O)C=C4)=O)C=C3)=N2)=C2N1CCC)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	2.52	5

Preparing Stock Solutions

The following data is based on the product molecular weight 503.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL
10 mM	0.2 mL	0.99 mL	1.99 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749

Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A_2B receptor. J.Pharmacol.Exp.Ther. 320 637 PMID: 17077318

Kiec-Kononowicz et al (2001) New developments in A₁ and A₂ adenosine receptor antagonists. Pure Appl.Chem. 73 1411 PMID:

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Keywords: MRS 1706, supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience